SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

Natural killer cells in antiviral immunity

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

Key Mechanisms of NK Cell Dysfunction Revealed

Cell Biochemistry & Function, Biochemistry Journal

The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy: Molecular Therapy - Oncolytics

Harnessing Natural Killer Cell-Mediated Innate Immune Responses for Cancer Treatment: Advances and Challenges

Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease

Research, Catherine Blish Lab

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

The Development of Natural Killer Cells for Solid Tumor Treatment