A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered

Researchers from the group Mitochondrial regulation of cell death and steatohepatitis have revealed a new role for acid ceramidase (ACDase) in experimental models and in patients with NPC through the regulation of STARD1 and its impact on mitochondrial function.

STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome

Lysosomal positioning diseases: beyond substrate storage

PDF) The pathogenesis of Niemann-Pick type C disease: A role for autophagy?

Lysosomal positioning diseases: beyond substrate storage

2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy

A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered

Frontiers Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease

Niemann-Pick type C disease: The atypical sphingolipidosis. - Abstract - Europe PMC

Frontiers Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association. - Abstract - Europe PMC