The Safety of High Dose Labetalol in the Pregnant Population

Hypertension in pregnancy is one of the leading causes of maternal mortality and rapid treatment is critical. Treatment of emergent hypertensive crises in pregnancy is limited to only three medications, one of which is labetalol. Current literature recommends a daily maximum intravenous labetalol dose of 300 mg per day. However, this maximum dose has not been studied in pregnancy where higher doses may be required.

530: Revisiting the limits of labetalol in the pregnant population: a Trinity Health system analysis - American Journal of Obstetrics & Gynecology

Oral nifedipine vs. intravenous labetalol for treatment of pregnancy‐induced severe pre‐eclampsia - Shi - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

Use of Medication for Cardiovascular Disease During Pregnancy: JACC State-of-the-Art Review

A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA), Trials

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